Transient Ikk Activity Mediates Nf-κb Temporal Dynamics in Response to a Wide Range of Tnfα Doses
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TRANSIENT IKK ACTIVITY MEDIATES NF-κB TEMPORAL DYNAMICS IN RESPONSE TO A WIDE RANGE OF TNFα DOSES Raymond Cheong, Adriel Bergmann, Shannon L. Werner, Joshua Regal, Alexander Hoffmann, Andre Levchenko From the 1 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218 and the 2 Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California, San Diego, San Diego, CA 92093 RUNNING TITLE: TNFα dose response mediated by IKK Address correspondence to: Andre Levchenko, Department of Biomedical Engineering, Johns Hopkins University, 208C Clark Hall, 3400 N. Charles St., Baltimore, MD 21218; Tel. 410-516-5584; Fax 410516-6240; E-mail: [email protected]
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تاریخ انتشار 2005